InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STC1

Summary

InnateDB Protein

IDBP-12226.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STC1

Protein Name

stanniocalcin 1

Synonyms

STC;

Species

Homo sapiens

Ensembl Protein

ENSP00000290271

InnateDB Gene

IDBG-12222 (STC1)

Protein Structure

UniProt Annotation

Function

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0001503	ossification
GO:0006874	cellular calcium ion homeostasis
GO:0007166	cell surface receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007566	embryo implantation
GO:0007584	response to nutrient
GO:0014070	response to organic cyclic compound
GO:0033280	response to vitamin D
GO:0046697	decidualization
GO:0071320	cellular response to cAMP
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071456	cellular response to hypoxia