InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BSG

Summary

InnateDB Protein

IDBP-12359.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BSG

Protein Name

basigin (Ok blood group)

Synonyms

5F7; CD147; EMMPRIN; M6; OK; TCSF;

Species

Homo sapiens

Ensembl Protein

ENSP00000333769

InnateDB Gene

IDBG-12353 (BSG)

Protein Structure

UniProt Annotation

Function

Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. {ECO:0000269PubMed:17127621}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Colocalizes with SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.

Disease Associations

Tissue Specificity

Present only in vascular endothelium in non- neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.

Experimentally validated
Total	35 [view]
Protein-Protein	34 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005537	mannose binding

Biological Process

GO:0006090	pyruvate metabolic process
GO:0007166	cell surface receptor signaling pathway
GO:0007566	embryo implantation
GO:0007596	blood coagulation
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043434	response to peptide hormone
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0046689	response to mercury ion
GO:0046697	decidualization
GO:0050900	leukocyte migration
GO:0051591	response to cAMP
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0000139	Golgi membrane
GO:0002080	acrosomal membrane
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF07679
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35613