InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MARCH6

Summary

InnateDB Protein

IDBP-12405.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MARCH6

Protein Name

membrane-associated ring finger (C3HC4) 6

Synonyms

DOA10; MARCH-VI; RNF176; TEB4;

Species

Homo sapiens

Ensembl Protein

ENSP00000274140

InnateDB Gene

IDBG-12403 (MARCH6)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. {ECO:0000269PubMed:15673284, ECO:0000269PubMed:19651899}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:15673284}; Multi-pass membrane protein {ECO:0000269PubMed:15673284}.

Disease Associations

Tissue Specificity

Present in brain (at protein level). {ECO:0000269PubMed:15673284}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019899	enzyme binding
GO:0031624	ubiquitin conjugating enzyme binding
GO:0046872	metal ion binding