Version 5.4
Homo sapiens Gene: MARCH6
Summary
InnateDB Gene IDBG-12403.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH6
Gene Name membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
Synonyms DOA10; MARCH-VI; RNF176; TEB4
Species Homo sapiens
Ensembl Gene ENSG00000145495
Encoded Proteins
IDBP-12405
membrane-associated ring finger (C3HC4) 6
IDBP-362271
membrane-associated ring finger (C3HC4) 6
IDBP-474382
membrane-associated ring finger (C3HC4) 6
IDBP-485041
membrane-associated ring finger (C3HC4) 6
IDBP-485080
membrane-associated ring finger (C3HC4) 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:10353703-10440388
Strand Forward strand
Band p15.2
Transcripts
ENST00000274140 ENSP00000274140
ENST00000449913 ENSP00000414643
ENST00000502795 ENSP00000426000
ENST00000511802
ENST00000503788 ENSP00000425930
ENST00000510872
ENST00000507863
ENST00000506131
ENST00000514961
ENST00000510792 ENSP00000424512
ENST00000512449
ENST00000505253
ENST00000514312
ENST00000606497
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0019899 enzyme binding
GO:0031624 ubiquitin conjugating enzyme binding
GO:0046872 metal ion binding
Biological Process
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039100
View Gene Order
ENSBTAG00000003536
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.432862 Hs.595061
RefSeq NM_001270660 NM_001270661 NM_005885
HUGO
OMIM
CCDS CCDS34135 CCDS59487 CCDS59488
HPRD 11095
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca