InnateDB Protein
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IDBP-1242.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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N6AMT1
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Protein Name
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N-6 adenine-specific DNA methyltransferase 1 (putative)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000286764
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InnateDB Gene
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IDBG-1238 (N6AMT1)
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Protein Structure
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Function |
Heterodimeric methyltransferase that catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. {ECO:0000269PubMed:18539146, ECO:0000269PubMed:21193388}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland. {ECO:0000269PubMed:21193388}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007848
Methyltransferase small domain
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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PFAM |
PF05175
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y5N5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
29104
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UniGene |
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RefSeq |
NP_877426
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HUGO |
HGNC:16021
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OMIM |
614553
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CCDS |
CCDS33525
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HPRD |
10739
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IMGT |
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EMBL |
AF139682
AF227510
AL163248
BC011554
CH471079
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GenPept |
AAD38520
AAH11554
CAB90428
EAX09941
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