InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HLA-C

Summary

InnateDB Protein

IDBP-124896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLA-C

Protein Name

major histocompatibility complex, class I, C

Synonyms

D6S204; HLA-JY3; HLC-C; PSORS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000372819

InnateDB Gene

IDBG-77290 (HLA-C)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042605	peptide antigen binding

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006955	immune response
GO:0019882	antigen processing and presentation

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042612	MHC class I protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR010579 MHC class I, alpha chain, C-terminal
IPR011162 MHC classes I/II-like antigen recognition protein
IPR027648 MHC class I alpha chain

PFAM

PF00129
PF07654
PF06623

PRINTS

PR01638

PIRSF

SMART

SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF017330 AJ507797 AL671883 DQ847464 EU484047 FJ392188 FJ392191 FJ392195 FJ392199 FJ392217 FJ392227 FJ392228 FJ489879 FJ538258 FJ594512 FJ614612 FJ619429 FJ619430 FJ765755 FJ765757 FJ792489 FJ792504 FJ792505 FJ875583 FJ875623 FJ976787 FJ976789 FJ976872 FJ997956 FJ997969 FJ997970 FJ997994 FN430610 FR675921 FR694927 FR716510 GQ121344 GQ149305 GQ149307 GQ149318 GQ161056 GQ161068 GQ161070 GQ161073 GQ180240 GQ180390 GQ180429 GQ180446 GQ240475 GQ254376 GQ266700 GQ345069 GQ345075 GQ345076 GQ401205 GQ401218 GQ900572 GQ994089 GU017939 GU017942 GU017943 GU128018 GU551860 GU551864 GU551874 GU551879 HE806312 HG934781 HM004248 HM068544 HM125859 HM125871 HM159351 HM159352 HM362831 HM362845 HM467551 HM562321 HM768857 HQ011352 HQ214996 HQ215005 HQ215007 HQ215018 HQ215026 HQ230498 HQ230508 HQ230517 HQ590470 HQ590471 HQ590480 HQ590486 HQ590487 HQ590489 HQ590492 HQ590514 HQ590516 HQ590517 HQ590519 HQ641387 HQ644398 HQ644404 HQ644405 HQ644407 HQ644411 HQ644412 HQ700658 HQ879820 JF292501 JF309414 JF309436 JN119435 JN119438 JN119442 JN119444 JN119445 JN119450 JN119452 JN119460 JN119461 JN119465 JN119466 JN119473 JN119476 JN123923 JN123924 JN123926 JN123930 JN123932 JN123945 JN123946 JN123947 JN123953 JN123954 JN123964 JN123967 JN123970 JN124398 JN124423 JN124478 JN124513 JN124526 JN124530 JN159891 JN159892 JN182993 JN205234 JN205235 JN406421 JN406466 JN406478 JN406479 JN418839 JN418840 JN561749 JN561752 JN561755 JN561758 JN629058 JN629064 JN644978 JN644979 JN675291 JN786898 JQ048686 JQ048688 JQ277306 JQ277309 JQ277310 JQ277311 JQ277312 JQ824443 JQ824494 JQ824496 JQ824528 JQ824551 JQ824592 JQ824600 JQ824624 JQ824625 JQ824626 JQ824632 JQ824633 JQ824634 JQ824635 JQ824639 JQ824641 JQ824645 JQ824647 JQ824652 JQ824653 JQ824657 JQ824659 JQ824660 JQ824661 JQ824665 JQ824667 JQ824670 JQ824674 JQ824679 JQ824680 JQ824686 JQ824692 JQ824693 JQ824694 JQ824696 JQ824698 JQ867336 JQ867339 JQ867340 JQ867342 JQ867349 JQ911919 JQ911921 JQ911923 JQ911926 JQ935226 JQ964654 JQ964669 JQ997143 JQ997147 JX174627 JX198689 JX228035 KC185442 KC185443 KC503873 KC748252 KF175454 KF175457 KF175460 KF175461 KF175462 KF175463 KF175464 KF175465 KF420838 KF420866 KF420884 KF420912 KF531572 KF531596 KF531602 KF944429 KF947527 U60217 Y16418 Y18499

GenPept

AAB03578 AAB70296 ABH10663 ACA51861 ACL34372 ACM78934 ACN81052 ACN81054 ACN90998 ACN91013 ACN91014 ACP27910 ACP27947 ACR54361 ACR54364 ACR54368 ACR54372 ACR54390 ACR54400 ACR54401 ACS27605 ACS27607 ACS27690 ACS36192 ACS36437 ACS36449 ACS36451 ACS36454 ACT66300 ACT76245 ACU02002 ACU27288 ACU27294 ACU27295 ACU78147 ACU78148 ACV40722 ACV40735 ACX81385 ACX81388 ACX81389 ADC32180 ADC32191 ADC32192 ADC32216 ADC45456 ADC45458 ADC45469 ADC79855 ADC79997 ADC80036 ADC80053 ADE58709 ADE58713 ADE58723 ADE58728 ADE72959 ADE73165 ADE73245 ADE73336 ADE73388 ADE73736 ADI75496 ADM72788 ADM72789 ADN92617 ADN92631 ADZ05549 ADZ05559 ADZ05568 ADZ73133 ADZ73145 AEF13128 AEF13908 AEF13909 AEF13918 AEF13924 AEF13925 AEF13927 AEF13930 AEF13952 AEF13954 AEF13955 AEF13957 AEF32518 AEI01061 AEI30813 AEI30819 AEI30820 AEI30822 AEI30826 AEI30827 AEI87638 AEJ22102 AEJ22103 AEJ90521 AEK94891 AEK95016 AEK95068 AEK95090 AEK95166 AEK95169 AEK95173 AEK95175 AEK95176 AEK95181 AEK95183 AEK95191 AEK95192 AEK95196 AEK95197 AEK95204 AEK95207 AEK95333 AEK95363 AEK95417 AEK95426 AEK95428 AEK95439 AEK95447 AEK95661 AEK95662 AEK95664 AEK95668 AEK95670 AEK95683 AEK95684 AEK95685 AEK95691 AEK95692 AEK95702 AEK95705 AEK95708 AEK96136 AEK96161 AEK96216 AEK96251 AEK96264 AEK96268 AEW23042 AEW23087 AEW23099 AEW23100 AEW90696 AEW90699 AEW90702 AEW90705 AEY80113 AEY80119 AFA42434 AFA42490 AFA42491 AFA42511 AFA42686 AFA42687 AFA42772 AFA42773 AFD36913 AFD36915 AFD37009 AFD37012 AFD37013 AFD37014 AFD37015 AFM77813 AFM77816 AFM77817 AFM77819 AFM77826 AFN88165 AFN88169 AFQ55482 AFQ62749 AFQ90230 AFZ93986 AFZ94037 AFZ94039 AFZ94071 AFZ94094 AFZ94135 AFZ94143 AFZ94167 AFZ94168 AFZ94169 AFZ94175 AFZ94176 AFZ94177 AFZ94178 AFZ94182 AFZ94184 AFZ94188 AFZ94190 AFZ94195 AFZ94196 AFZ94200 AFZ94202 AFZ94203 AFZ94204 AFZ94208 AFZ94210 AFZ94213 AFZ94217 AFZ94222 AFZ94223 AFZ94229 AFZ94235 AFZ94236 AFZ94237 AFZ94239 AFZ94241 AFZ94440 AFZ94442 AFZ94444 AFZ94447 AFZ94475 AFZ94505 AFZ94520 AGG79907 AGG79908 AGK07572 AGK44327 AGQ16948 AGQ16951 AGQ16954 AGQ16955 AGQ16956 AGQ16957 AGQ16958 AGQ16959 AGZ87735 AGZ87763 AGZ87781 AGZ87809 AHA93024 AHA93048 AHA93054 AHG55094 AHK05785 CAA76206 CAB71315 CAD47827 CAZ86762 CBW44109 CBX25669 CBX45594 CCH57809 CDN33434

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca