Version 5.4
Homo sapiens Protein: GZMM
Summary
InnateDB Protein IDBP-12499.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GZMM
Protein Name granzyme M (lymphocyte met-ase 1)
Synonyms LMET1; MET1;
Species Homo sapiens
Ensembl Protein ENSP00000264553
InnateDB Gene IDBG-12497 (GZMM)
Protein Structure
UniProt Annotation
Function Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. {ECO:0000269PubMed:18523284, ECO:0000269PubMed:20406824}.
Subcellular Localization Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes.
Disease Associations
Tissue Specificity Highly and constitutively expressed in activated natural killer (NK) cells. {ECO:0000269PubMed:18523284}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0019835 cytolysis
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51124
PhosphoSite PhosphoSite-P51124
TrEMBL
UniProt Splice Variant
Entrez Gene 3004
UniGene Hs.465511
RefSeq NP_005308
HUGO HGNC:4712
OMIM 600311
CCDS CCDS12031
HPRD 02633
IMGT
EMBL AC011556 BC025701 L23134 L36922 L36936
GenPept AAA57257 AAA57262 AAA59582 AAH25701

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca