Version 5.4
Homo sapiens Protein: RNMT
Summary
InnateDB Protein IDBP-1260.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNMT
Protein Name RNA (guanine-7-) methyltransferase
Synonyms hCMT1c; MET; RG7MT1;
Species Homo sapiens
Ensembl Protein ENSP00000372804
InnateDB Gene IDBG-1256 (RNMT)
Protein Structure
UniProt Annotation
Function mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC. {ECO:0000269PubMed:10347220, ECO:0000269PubMed:22099306, ECO:0000269PubMed:9705270, ECO:0000269PubMed:9790902}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11114884, ECO:0000269PubMed:15767670}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:9705270, ECO:0000269PubMed:9790902}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004482 mRNA (guanine-N7-)-methyltransferase activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0008152 metabolic process
GO:0010467 gene expression
GO:0016032 viral process
GO:0036265 RNA (guanine-N7)-methylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005845 mRNA cap binding complex
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR004971 mRNA (guanine-N(7))-methyltransferase domain
IPR013216 Methyltransferase type 11
IPR016899 mRNA (guanine-N(7))-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF03291
PF08241
PRINTS
PIRSF PIRSF028762
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43148
PhosphoSite PhosphoSite-O43148
TrEMBL Q9UEB8
UniProt Splice Variant
Entrez Gene 8731
UniGene Hs.8086
RefSeq NP_003790
HUGO HGNC:10075
OMIM 603514
CCDS CCDS11867
HPRD 04622
IMGT
EMBL AB007858 AB020966 AB022604 AB022605 AB022606 AF067791 AP001525 BC036798 CH471113 EF445026
GenPept AAC63269 AAH36798 ACA06068 BAA23694 BAA74462 BAA74463 BAA74464 BAA82447 EAX01505 EAX01506

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca