Mus musculus Protein: Kdm5d
Summary
InnateDB Protein IDBP-127665.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kdm5d
Protein Name lysine (K)-specific demethylase 5D
Synonyms HY; Jarid1d; Smcy;
Species Mus musculus
Ensembl Protein ENSMUSP00000061095
InnateDB Gene IDBG-127663 (Kdm5d)
Protein Structure
UniProt Annotation
Function Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00355, ECO:0000255PROSITE-ProRule:PRU00537}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032453 histone demethylase activity (H3-K4 specific)
Biological Process
GO:0034720 histone H3-K4 demethylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:99780
InterPro IPR001606 ARID/BRIGHT DNA-binding domain
IPR001965 Zinc finger, PHD-type
IPR003347 JmjC domain
IPR003349 Transcription factor jumonji, JmjN
IPR004198 Zinc finger, C5HC2-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR013637 Lysine-specific demethylase-like domain
IPR019787 Zinc finger, PHD-finger
PFAM PF01388
PF02373
PF08007
PF02375
PF02928
PF08429
PF00628
PRINTS
PIRSF
SMART SM00501
SM00249
SM00558
SM00545
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62240
PhosphoSite PhosphoSite-Q62240
TrEMBL
UniProt Splice Variant
Entrez Gene 20592
UniGene Mm.428271
RefSeq NP_035549
MGI ID
MGI Symbol Kdm5d
OMIM
CCDS CCDS30541
HPRD
IMGT
EMBL AF127244 AK140971 BC059077 Z29652
GenPept AAD53048 AAH59077 BAE24534 CAA82760