InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ONECUT1

Summary

InnateDB Protein

IDBP-12784.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ONECUT1

Protein Name

one cut homeobox 1

Synonyms

HNF-6; HNF6; HNF6A;

Species

Homo sapiens

Ensembl Protein

ENSP00000302630

InnateDB Gene

IDBG-12782 (ONECUT1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in liver; lower expression in testis and skin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 306 experimentally validated interaction(s) in this database.

Experimentally validated
Total	306 [view]
Protein-Protein	9 [view]
Protein-DNA	296 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001889	liver development
GO:0001952	regulation of cell-matrix adhesion
GO:0002064	epithelial cell development
GO:0006006	glucose metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007492	endoderm development
GO:0009653	anatomical structure morphogenesis
GO:0030154	cell differentiation
GO:0030183	B cell differentiation
GO:0030335	positive regulation of cell migration
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031016	pancreas development
GO:0031018	endocrine pancreas development
GO:0042384	cilium assembly
GO:0045165	cell fate commitment
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048536	spleen development