InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pomc

Summary

InnateDB Protein

IDBP-127852.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pomc

Protein Name

pro-opiomelanocortin-alpha

Synonyms

ACTH; alpha-MSH; alphaMSH; BE; Beta-LPH; beta-MSH; Clip; Gamma-LPH; gamma-MSH; Npp; Pomc-1; Pomc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020990

InnateDB Gene

IDBG-127850 (Pomc)

Protein Structure

UniProt Annotation

Function

ACTH stimulates the adrenal glands to release cortisol.MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.Beta-endorphin and Met-enkephalin are endogenous opiates.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

ACTH and MSH are produced by the pituitary gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0031781	type 3 melanocortin receptor binding
GO:0031782	type 4 melanocortin receptor binding
GO:0070996	type 1 melanocortin receptor binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0007165	signal transduction
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0008217	regulation of blood pressure
GO:0032098	regulation of appetite
GO:0032720	negative regulation of tumor necrosis factor production
GO:0033059	cellular pigmentation
GO:0042593	glucose homeostasis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070873	regulation of glycogen metabolic process
GO:2000852	regulation of corticosterone secretion

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005782	peroxisomal matrix
GO:0030141	secretory granule

Protein Structure and Domains

PDB ID

MGI:97742

InterPro

IPR001941 Pro-opiomelanocortin/corticotropin, ACTH
IPR013531 Pro-opiomelanocortin/corticotropin, ACTH, central region
IPR013532 Opiodes neuropeptide
IPR013593 Pro-opiomelanocortin N-terminal

PFAM

PF00976
PF08035
PF08384

PRINTS

PR00383

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P01193