InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NME8

Summary

InnateDB Protein

IDBP-12787.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NME8

Protein Name

thioredoxin domain containing 3 (spermatozoa)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000199447

InnateDB Gene

IDBG-12785 (NME8)

Protein Structure

UniProt Annotation

Function

Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11737268}.

Disease Associations

Ciliary dyskinesia, primary, 6 (CILD6) [MIM:610852]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. {ECO:0000269PubMed:17360648}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Testis-specific. Expressed only in primary spermatocytes and round spermatids. {ECO:0000269PubMed:11737268}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding

Biological Process

GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0045454	cell redox homeostasis