Homo sapiens Gene: NME8
Summary
InnateDB Gene IDBG-12785.6
Last Modified 2013-04-25 [Report errors or provide feedback]
Gene Symbol NME8
Gene Name NME/NM23 family member 8
Synonyms CILD6; NM23-H8; sptrx-2; SPTRX2; TXNDC3;
Species Homo sapiens
Ensembl Gene ENSG00000086288
Encoded Proteins
thioredoxin domain containing 3 (spermatozoa)
thioredoxin domain containing 3 (spermatozoa)
thioredoxin domain containing 3 (spermatozoa)
thioredoxin domain containing 3 (spermatozoa)
thioredoxin domain containing 3 (spermatozoa)
Protein Structure
Entrez Gene
Summary This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:37888199-37940003
Strand Forward strand
Band p14.1
Transcripts
ENST00000199447 ENSP00000199447
ENST00000455500 ENSP00000390047
ENST00000444718 ENSP00000390596
ENST00000440017 ENSP00000397063
ENST00000426106 ENSP00000408841
ENST00000476435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004550 nucleoside diphosphate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006183 GTP biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q8N427
TrEMBL C9JG62 C9JIT0 F8WEA2
UniProt Splice Variant
Entrez Gene 51314
UniGene Hs.723454
RefSeq NM_016616
HUGO 16473
OMIM 607421
CCDS CCDS5452
HPRD 16243
IMGT
EMBL AC018634 AF202051 AF305596 BC036816
GenPept AAF20909 AAH36816 AAN04258
ImmGen NME8 (murine)
RNA Seq Atlas 51314