InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itsn2

Summary

InnateDB Protein

IDBP-127957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itsn2

Protein Name

intersectin 2

Synonyms

AI327390; Ese2; mKIAA1256; Sh3d1B; Sh3p18;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052758

InnateDB Gene

IDBG-127955 (Itsn2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	75 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006897	endocytosis
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction

Cellular Component

GO:0070062

extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1338049

InterPro

IPR000008 C2 domain
IPR000219 Dbl homology (DH) domain
IPR000261 EPS15 homology (EH)
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR011511 Variant SH3 domain

PFAM