Version 5.4
Mus musculus Gene: Itsn2
Summary
InnateDB Gene IDBG-127955.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itsn2
Gene Name intersectin 2
Synonyms AI327390; Ese2; mKIAA1256; Sh3d1B; Sh3p18
Species Mus musculus
Ensembl Gene ENSMUSG00000020640
Encoded Proteins
IDBP-127957
intersectin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198399:
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:4593008-4713950
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000062580 ENSMUSP00000052758
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 75 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006897 endocytosis
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198399
View Gene Order
ENSBTAG00000023172
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL E9QNG1 Q3V3Y8 Q80TG5
UniProt Splice Variant
Entrez Gene 20403
UniGene Mm.489427
RefSeq NM_001198968 NM_001198969 NM_011365
OMIM
CCDS CCDS36398
HPRD
IMGT
MGI ID MGI:1338049
MGI Symbol Itsn2
EMBL AC158232 AC241534 AK029325 AK122480 CT025683
GenPept BAC65762 BAE43269
RNA Seq Atlas 20403

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca