InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pon1

Summary

InnateDB Protein

IDBP-128049.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pon1

Protein Name

paraoxonase 1

Synonyms

Pon;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002663

InnateDB Gene

IDBG-128047 (Pon1)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Plasma, liver, kidney, heart, brain, small intestine and lung. In the plasma, associated with HDL.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004063	aryldialkylphosphatase activity
GO:0004064	arylesterase activity
GO:0005509	calcium ion binding
GO:0005543	phospholipid binding
GO:0008035	high-density lipoprotein particle binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006629	lipid metabolic process
GO:0008015	blood circulation
GO:0008203	cholesterol metabolic process
GO:0009636	response to toxic substance
GO:0010875	positive regulation of cholesterol efflux
GO:0016311	dephosphorylation
GO:0019439	aromatic compound catabolic process
GO:0031667	response to nutrient levels
GO:0032411	positive regulation of transporter activity
GO:0046395	carboxylic acid catabolic process
GO:0046434	organophosphate catabolic process
GO:0046470	phosphatidylcholine metabolic process
GO:0051099	positive regulation of binding
GO:0070542	response to fatty acid
GO:1902617	response to fluoride

Cellular Component

GO:0005615	extracellular space
GO:0034366	spherical high-density lipoprotein particle
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle