InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pon3

Summary

InnateDB Protein

IDBP-128061.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pon3

Protein Name

paraoxonase 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031773

InnateDB Gene

IDBG-128059 (Pon3)

Protein Structure

UniProt Annotation

Function

Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004063	aryldialkylphosphatase activity
GO:0004064	arylesterase activity
GO:0016844	strictosidine synthase activity
GO:0018733	3,4-dihydrocoumarin hydrolase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0047856	dihydrocoumarin hydrolase activity

Biological Process

GO:0009058	biosynthetic process
GO:0010124	phenylacetate catabolic process
GO:0016311	dephosphorylation
GO:0019439	aromatic compound catabolic process
GO:0046226	coumarin catabolic process
GO:0046395	carboxylic acid catabolic process