Version 5.4
Mus musculus Gene: Pon3
Summary
InnateDB Gene IDBG-128059.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pon3
Gene Name paraoxonase 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000029759
Encoded Proteins
IDBP-128061
paraoxonase 3
IDBP-538301
paraoxonase 3
IDBP-716121
IDBP-716523
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105852:
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:5220852-5256286
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000031773 ENSMUSP00000031773
ENSMUST00000129344 ENSMUSP00000118137
ENSMUST00000125686 ENSMUSP00000135603
ENSMUST00000156848
ENSMUST00000176039
ENSMUST00000176948 ENSMUSP00000135554
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004063 aryldialkylphosphatase activity
GO:0004064 arylesterase activity
GO:0016844 strictosidine synthase activity
GO:0018733 3,4-dihydrocoumarin hydrolase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0047856 dihydrocoumarin hydrolase activity
Biological Process
GO:0009058 biosynthetic process
GO:0010124 phenylacetate catabolic process
GO:0016311 dephosphorylation
GO:0019439 aromatic compound catabolic process
GO:0046226 coumarin catabolic process
GO:0046395 carboxylic acid catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105852
View Gene Order
ENSBTAG00000034645
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.417350 Mm.9122
RefSeq NM_173006 XM_006505088 XM_006505089
OMIM
CCDS CCDS19899
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca