Version 5.4
| Mus musculus Protein: C9 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Protein | IDBP-128083.6 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | C9 | ||||||||||||
| Protein Name | complement component 9 | ||||||||||||
| Synonyms | |||||||||||||
| Species | Mus musculus | ||||||||||||
| Ensembl Protein | ENSMUSP00000022749 | ||||||||||||
| InnateDB Gene | IDBG-128081 (C9) | ||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||
| Function | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. | ||||||||||||
| Subcellular Localization | Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore (By similarity). {ECO:0000250}. | ||||||||||||
| Disease Associations | |||||||||||||
| Tissue Specificity | |||||||||||||
| Comments | |||||||||||||
| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||
| PDB ID | MGI:1098282 | ||||||||||||
| InterPro |
IPR000884
Thrombospondin, type 1 repeat IPR001862 Membrane attack complex component/perforin/complement C9 IPR002172 Low-density lipoprotein (LDL) receptor class A repeat IPR020864 Membrane attack complex component/perforin (MACPF) domain |
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| PFAM |
PF00090
PF00057 PF01823 |
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| PRINTS |
PR00764
PR00261 |
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| PIRSF | |||||||||||||
| SMART |
SM00209
SM00192 SM00457 |
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| TIGRFAMs | |||||||||||||
| Post-translational Modifications | |||||||||||||
| Modification | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | P06683 | ||||||||||||
| PhosphoSite | PhosphoSite-P06683 | ||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 12279 | ||||||||||||
| UniGene | Mm.29095 | ||||||||||||
| RefSeq | NP_038513 | ||||||||||||
| MGI ID | |||||||||||||
| MGI Symbol | C9 | ||||||||||||
| OMIM | |||||||||||||
| CCDS | CCDS27367 | ||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | BC011137 X05475 | ||||||||||||
| GenPept | AAH11137 CAA29038 | ||||||||||||