Version 5.4
Mus musculus Gene: C9
Summary
InnateDB Gene IDBG-128081.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C9
Gene Name complement component 9
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000022149
Encoded Proteins
IDBP-128083
complement component 9
IDBP-743803
IDBP-744171
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 16189651
[Homo sapiens] C9, Complement factor nine, is one of five components that interact to form the cytolytic membrane attack complex (MAC), composed of a C5B-C8 complex attached to a transmembrane C9 oligomer.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113600:
This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:6445327-6498751
Strand Forward strand
Band A1
Transcripts
ENSMUST00000022749 ENSMUSP00000022749
ENSMUST00000128097 ENSMUSP00000135614
ENSMUST00000127196
ENSMUST00000147905 ENSMUSP00000135459
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0019835 cytolysis
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113600
View Gene Order
ENSBTAG00000016149
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_208792
Complement cascade pathway
REACT_198562
Regulation of Complement cascade pathway
REACT_230745
Immune System pathway
REACT_215211
Terminal pathway of complement pathway
KEGG
mmu04610
Complement and coagulation cascades pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05020
Prion diseases pathway
mmu05146
Amoebiasis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_8028
Terminal pathway of complement pathway
REACT_118707
Regulation of Complement cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
REACT_221307
Terminal pathway of complement pathway
REACT_213138
Immune System pathway
REACT_223001
Regulation of Complement cascade pathway
REACT_209085
Complement cascade pathway
REACT_216714
Innate Immune System pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05020
Prion diseases pathway
hsa05146
Amoebiasis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 12279
UniGene Mm.29095
RefSeq NM_013485
OMIM
CCDS CCDS27367
HPRD
IMGT
MGI ID MGI:1098282
MGI Symbol C9
EMBL
GenPept
RNA Seq Atlas 12279

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca