InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Asb4

Summary

InnateDB Protein

IDBP-128120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Asb4

Protein Name

ankyrin repeat and SOCS box-containing 4

Synonyms

8430401O13Rik; AV117194; AW060255;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040331

InnateDB Gene

IDBG-128118 (Asb4)

Protein Structure

UniProt Annotation

Function

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism. {ECO:0000269PubMed:17636018}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highest expression detected in testis, with some expression detected in ovary and heart. Not detected in lung, kidney, liver, spleen and bone marrow. {ECO:0000269PubMed:11111040, ECO:0000269PubMed:17636018}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding