Version 5.4
Mus musculus Gene: Asb4
Summary
InnateDB Gene IDBG-128118.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asb4
Gene Name ankyrin repeat and SOCS box-containing 4
Synonyms 8430401O13Rik; AV117194; AW060255
Species Mus musculus
Ensembl Gene ENSMUSG00000042607
Encoded Proteins
IDBP-128120
ankyrin repeat and SOCS box-containing 4
IDBP-789753
ankyrin repeat and SOCS box-containing 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005981:
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:5383386-5433022
Strand Forward strand
Band A1
Transcripts
ENSMUST00000043294 ENSMUSP00000040331
ENSMUST00000183358 ENSMUSP00000139245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0035556 intracellular signal transduction
GO:0051865 protein autoubiquitination
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0031466 Cul5-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000005981
View Gene Order
ENSBTAG00000018185
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q3V229
UniProt Splice Variant
Entrez Gene 65255
UniGene
RefSeq NM_023048 XM_006505159
OMIM
CCDS CCDS19901
HPRD
IMGT
MGI ID MGI:1929751
MGI Symbol Asb4
EMBL AC023285 AC119865 AK132068
GenPept BAE20970
RNA Seq Atlas 65255

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca