InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apob

Summary

InnateDB Protein

IDBP-128211.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Apob

Protein Name

apolipoprotein B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036044

InnateDB Gene

IDBG-128209 (Apob)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005319	lipid transporter activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008201	heparin binding
GO:0008289	lipid binding
GO:0017127	cholesterol transporter activity
GO:0019899	enzyme binding
GO:0035473	lipase binding
GO:0046982	protein heterodimerization activity
GO:0050750	low-density lipoprotein particle receptor binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006629	lipid metabolic process
GO:0006642	triglyceride mobilization
GO:0006869	lipid transport
GO:0007283	spermatogenesis
GO:0007399	nervous system development
GO:0008203	cholesterol metabolic process
GO:0009566	fertilization
GO:0009615	response to virus
GO:0009743	response to carbohydrate
GO:0009791	post-embryonic development
GO:0010033	response to organic substance
GO:0010269	response to selenium ion
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010884	positive regulation of lipid storage
GO:0010886	positive regulation of cholesterol storage
GO:0016042	lipid catabolic process
GO:0019433	triglyceride catabolic process
GO:0030301	cholesterol transport
GO:0030317	sperm motility
GO:0032496	response to lipopolysaccharide
GO:0033344	cholesterol efflux
GO:0034374	low-density lipoprotein particle remodeling
GO:0034383	low-density lipoprotein particle clearance
GO:0042157	lipoprotein metabolic process
GO:0042158	lipoprotein biosynthetic process
GO:0042159	lipoprotein catabolic process
GO:0042632	cholesterol homeostasis
GO:0042953	lipoprotein transport
GO:0045540	regulation of cholesterol biosynthetic process
GO:0048844	artery morphogenesis
GO:0071356	cellular response to tumor necrosis factor
GO:0071379	cellular response to prostaglandin stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0012506	vesicle membrane
GO:0015629	actin cytoskeleton
GO:0031983	vesicle lumen
GO:0034359	mature chylomicron
GO:0034361	very-low-density lipoprotein particle
GO:0034362	low-density lipoprotein particle
GO:0034363	intermediate-density lipoprotein particle
GO:0042627	chylomicron
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:88052

InterPro

IPR001747 Lipid transport protein, N-terminal
IPR009454 Lipid transport, open beta-sheet
IPR011030 Vitellinogen, superhelical
IPR015255 Vitellinogen, open beta-sheet
IPR015819 Lipid transport protein, beta-sheet shell
IPR022176 Apolipoprotein B100 C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01347
PF06448
PF09172
PF12491

PRINTS

PIRSF

SMART

SM00638

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

E9Q414