Version 5.4
Mus musculus Gene: Apob
Summary
InnateDB Gene IDBG-128209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apob
Gene Name apolipoprotein B
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020609
Encoded Proteins
IDBP-128211
apolipoprotein B
IDBP-128213
apolipoprotein B
IDBP-622800
apolipoprotein B
IDBP-622812
apolipoprotein B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the mouse apoB-48 isoform is also found in mouse liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2179 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:7977648-8016835
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000037811 ENSMUSP00000036044
ENSMUST00000037520 ENSMUSP00000035761
ENSMUST00000171271 ENSMUSP00000127147
ENSMUST00000171239 ENSMUSP00000129496
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005319 lipid transporter activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008201 heparin binding
GO:0008289 lipid binding
GO:0017127 cholesterol transporter activity
GO:0019899 enzyme binding
GO:0035473 lipase binding
GO:0046982 protein heterodimerization activity
GO:0050750 low-density lipoprotein particle receptor binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006629 lipid metabolic process
GO:0006642 triglyceride mobilization
GO:0006869 lipid transport
GO:0007283 spermatogenesis
GO:0007399 nervous system development
GO:0008203 cholesterol metabolic process
GO:0009566 fertilization
GO:0009615 response to virus
GO:0009743 response to carbohydrate
GO:0009791 post-embryonic development
GO:0010033 response to organic substance
GO:0010269 response to selenium ion
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010884 positive regulation of lipid storage
GO:0010886 positive regulation of cholesterol storage
GO:0016042 lipid catabolic process
GO:0019433 triglyceride catabolic process
GO:0030301 cholesterol transport
GO:0030317 sperm motility
GO:0032496 response to lipopolysaccharide
GO:0033344 cholesterol efflux
GO:0034374 low-density lipoprotein particle remodeling
GO:0034383 low-density lipoprotein particle clearance
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042159 lipoprotein catabolic process
GO:0042632 cholesterol homeostasis
GO:0042953 lipoprotein transport
GO:0045540 regulation of cholesterol biosynthetic process
GO:0048844 artery morphogenesis
GO:0071356 cellular response to tumor necrosis factor
GO:0071379 cellular response to prostaglandin stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0012506 vesicle membrane
GO:0015629 actin cytoskeleton
GO:0031983 vesicle lumen
GO:0034359 mature chylomicron
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0034363 intermediate-density lipoprotein particle
GO:0042627 chylomicron
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000084674
View Gene Order
ENSBTAG00000008505
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_208483
Platelet homeostasis pathway
REACT_224553
Hemostasis pathway
REACT_198569
Retinoid metabolism and transport pathway
REACT_222614
LDL-mediated lipid transport pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_188937
Metabolism pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_196581
Scavenging by Class A Receptors pathway
REACT_238381
Lipid digestion, mobilization, and transport pathway
REACT_250548
Platelet sensitization by LDL pathway
REACT_216017
Chylomicron-mediated lipid transport pathway
REACT_211709
Lipoprotein metabolism pathway
REACT_196603
Scavenging by Class F Receptors pathway
REACT_188260
Visual phototransduction pathway
REACT_188257
Signal Transduction pathway
REACT_188255
Diseases associated with visual transduction pathway
REACT_196594
Scavenging by Class H Receptors pathway
REACT_196592
Scavenging by Class B Receptors pathway
KEGG
mmu04975
Fat digestion and absorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23879
Platelet sensitization by LDL pathway
REACT_23876
Platelet homeostasis pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_24968
Retinoid metabolism and transport pathway
REACT_6841
Chylomicron-mediated lipid transport pathway
REACT_6934
LDL-mediated lipid transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_164002
Scavenging by Class H Receptors pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_163813
Scavenging by Class F Receptors pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_111102
Signal Transduction pathway
REACT_163699
Scavenging by Class A Receptors pathway
REACT_267716
Orphan transporters pathway
REACT_163679
Scavenging by Class B Receptors pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_6823
Lipoprotein metabolism pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04975
Fat digestion and absorption pathway
INOH
PID NCI
hnf3apathway
FOXA1 transcription factor network
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt E9Q414
TrEMBL E9Q1Y3 E9Q4G4 F7A3M3
UniProt Splice Variant
Entrez Gene 238055
UniGene Mm.221239
RefSeq NM_009693 XM_006515078
OMIM
CCDS CCDS49022
HPRD
IMGT
MGI ID MGI:88052
MGI Symbol Apob
EMBL AC163900 AK147540 BC038263 BC100607 BC141357 BC141360 M35186 X15191
GenPept AAA37246 AAH38263 AAI00608 AAI41358 AAI41361 BAE27983 CAA33265
RNA Seq Atlas 238055

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca