InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Usp14

Summary

InnateDB Protein

IDBP-128324.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp14

Protein Name

ubiquitin specific peptidase 14

Synonyms

2610005K12Rik; 2610037B11Rik; AW107924; ax; C78769; nmf375;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089728

InnateDB Gene

IDBG-128322 (Usp14)

Protein Structure

UniProt Annotation

Function

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Maintains the cellular levels of monomeric ubiquitin in cells. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor cxcr4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. {ECO:0000269PubMed:16190881, ECO:0000269PubMed:19726649}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0004866	endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0036459	ubiquitinyl hydrolase activity
GO:0070628	proteasome binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007268	synaptic transmission
GO:0010951	negative regulation of endopeptidase activity
GO:0016579	protein deubiquitination
GO:0050920	regulation of chemotaxis
GO:0061136	regulation of proteasomal protein catabolic process

Cellular Component

GO:0000502	proteasome complex
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:1928898

InterPro

IPR000626 Ubiquitin-like
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00240
PF14560
PF00443

PRINTS

PIRSF

SMART

SM00213

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JMA1