Version 5.4
Mus musculus Protein: Suv420h1
Summary
InnateDB Protein IDBP-128374.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Suv420h1
Protein Name suppressor of variegation 4-20 homolog 1 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000005518
InnateDB Gene IDBG-128370 (Suv420h1)
Protein Structure
UniProt Annotation
Function Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. {ECO:0000269PubMed:15145825, ECO:0000269PubMed:23720823}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15145825}. Chromosome {ECO:0000269PubMed:15145825}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042799 histone methyltransferase activity (H4-K20 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016571 histone methylation
GO:0034770 histone H4-K20 methylation
GO:0034773 histone H4-K20 trimethylation
Cellular Component
GO:0000780 condensed nuclear chromosome, centromeric region
Protein Structure and Domains
PDB ID MGI:2444557
InterPro IPR001214 SET domain
PFAM PF00856
PRINTS
PIRSF
SMART SM00317
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3U8K7
PhosphoSite PhosphoSite-Q3U8K7
TrEMBL H3BKZ5
UniProt Splice Variant
Entrez Gene 225888
UniGene Mm.472360
RefSeq
MGI ID 4BUP
MGI Symbol Suv420h1
OMIM
CCDS CCDS50345
HPRD
IMGT
EMBL AC132452 AK036880 AK054093 AK082660 AK083227 AK087267 AK139255 AK152179 AY555192 BC011214 BC075709
GenPept AAH11214 AAH75709 AAT00539 BAC29617 BAC35652 BAC38565 BAC38817 BAC39834 BAE23934 BAE31010

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca