InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plag1

Summary

InnateDB Protein

IDBP-128433.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plag1

Protein Name

pleiomorphic adenoma gene 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003369

InnateDB Gene

IDBG-128431 (Plag1)

Protein Structure

UniProt Annotation

Function

Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Cooperates with CBFB-MYH11. {ECO:0000269PubMed:15044690, ECO:0000269PubMed:15930271, ECO:0000269PubMed:16108035}.

Subcellular Localization

Nucleus. Note=Strong nucleolar localization when sumoylation is inhibited. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, spleen, lung, kidney, brain, testis and epididymis but not in salivary glands. {ECO:0000269PubMed:16193498}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0022612	gland morphogenesis
GO:0035264	multicellular organism growth
GO:0035265	organ growth
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060252	positive regulation of glial cell proliferation
GO:0060736	prostate gland growth