Version 5.4
Mus musculus Gene: Plag1
Summary
InnateDB Gene IDBG-128431.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plag1
Gene Name pleiomorphic adenoma gene 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000003282
Encoded Proteins
IDBP-128433
pleiomorphic adenoma gene 1
IDBP-536936
pleiomorphic adenoma gene 1
IDBP-540314
pleiomorphic adenoma gene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181690:
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:3900996-3938423
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000003369 ENSMUSP00000003369
ENSMUST00000137439 ENSMUSP00000117532
ENSMUST00000151543 ENSMUSP00000119937
ENSMUST00000147035
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0022612 gland morphogenesis
GO:0035264 multicellular organism growth
GO:0035265 organ growth
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060252 positive regulation of glial cell proliferation
GO:0060736 prostate gland growth
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000181690
View Gene Order
ENSBTAG00000004022
Not yet available
Cross-References
SwissProt Q9QYE0
TrEMBL
UniProt Splice Variant
Entrez Gene 56711
UniGene Mm.331467
RefSeq NM_019969 XM_006538116 XM_006538117 XM_006538118 XM_006538119
OMIM
CCDS CCDS17941
HPRD
IMGT
MGI ID MGI:1891916
MGI Symbol Plag1
EMBL AF057366 AK135759 AL807387 AY574219 BC139283 BC139285 CH466538
GenPept AAF21762 AAI39284 AAI39286 AAS86161 BAE22643 CAM18646 EDL05712
RNA Seq Atlas 56711

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca