InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndufa4

Summary

InnateDB Protein

IDBP-128497.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufa4

Protein Name

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4

Synonyms

MLRQ;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031637

InnateDB Gene

IDBG-128495 (Ndufa4)

Protein Structure

UniProt Annotation

Function

Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004129	cytochrome-c oxidase activity
GO:0032403	protein complex binding

Biological Process

GO:0055114	oxidation-reduction process
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I
GO:0005751	mitochondrial respiratory chain complex IV
GO:0070062	extracellular vesicular exosome