InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Penk

Summary

InnateDB Protein

IDBP-128500.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Penk

Protein Name

preproenkephalin

Synonyms

AI326464; ENK; Penk1; PPA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066822

InnateDB Gene

IDBG-128498 (Penk)

Protein Structure

UniProt Annotation

Function

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(238-259) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Spermatogenic and somatic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001515	opioid peptide activity
GO:0005515	protein binding

Biological Process

GO:0001662	behavioral fear response
GO:0001964	startle response
GO:0002118	aggressive behavior
GO:0007218	neuropeptide signaling pathway
GO:0007626	locomotory behavior
GO:0019233	sensory perception of pain