InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sdcbp

Summary

InnateDB Protein

IDBP-128599.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sdcbp

Protein Name

syndecan binding protein

Synonyms

MDA-9; Sycl; syntenin-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029912

InnateDB Gene

IDBG-128595 (Sdcbp)

Protein Structure

UniProt Annotation

Function

Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.

Subcellular Localization

Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005109	frizzled binding
GO:0005137	interleukin-5 receptor binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019838	growth factor binding
GO:0042043	neurexin family protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0045545	syndecan binding
GO:0046875	ephrin receptor binding
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007265	Ras protein signal transduction
GO:0042327	positive regulation of phosphorylation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005895	interleukin-5 receptor complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle