InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sdcbp

Summary

InnateDB Gene

IDBG-128595.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sdcbp

Gene Name

syndecan binding protein

Synonyms

MDA-9; Sycl; syntenin-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028249

Encoded Proteins

IDBP-128597

syndecan binding protein

IDBP-128599

syndecan binding protein

IDBP-264671

syndecan binding protein

IDBP-536827

syndecan binding protein

IDBP-533863

syndecan binding protein

IDBP-718576

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137575:
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:6365650-6408423

Strand

Forward strand

Band

Transcripts

ENSMUST00000103008	ENSMUSP00000100073
ENSMUST00000029912	ENSMUSP00000029912
ENSMUST00000108374	ENSMUSP00000104011
ENSMUST00000108371
ENSMUST00000155247
ENSMUST00000140830	ENSMUSP00000122411
ENSMUST00000153861	ENSMUSP00000119838
ENSMUST00000175769	ENSMUSP00000135777

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005109	frizzled binding
GO:0005137	interleukin-5 receptor binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019838	growth factor binding
GO:0042043	neurexin family protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0045545	syndecan binding
GO:0046875	ephrin receptor binding
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007265	Ras protein signal transduction
GO:0042327	positive regulation of phosphorylation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005895	interleukin-5 receptor complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle