InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shroom4

Summary

InnateDB Protein

IDBP-128789.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shroom4

Protein Name

shroom family member 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100070

InnateDB Gene

IDBG-128787 (Shroom4)

Protein Structure

UniProt Annotation

Function

Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II. {ECO:0000269PubMed:17009331}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:17009331}. Note=Shows partial colocalization with the cytoplasmic pool of F-actin.

Disease Associations

Tissue Specificity

Detected in most adult tissues examined. Expressed in brain, lung, heart, liver, kidney, muscle and ovary. Expressed throughout the brain, with high expression in the brain stem and cerebellum and weaker expression in the hypothalamus, the hippocampus and the olfactory bulb. Expressed in wide range of cell types during developpment, including vascular endothelium and the polarized epithelium of the neural tube and kidney. {ECO:0000269PubMed:16249884, ECO:0000269PubMed:17009331}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051015	actin filament binding

Biological Process

GO:0000902	cell morphogenesis
GO:0007015	actin filament organization
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0050890	cognition

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009898	cytoplasmic side of plasma membrane
GO:0009925	basal plasma membrane
GO:0015629	actin cytoskeleton
GO:0016324	apical plasma membrane
GO:0016460	myosin II complex
GO:0030864	cortical actin cytoskeleton
GO:0031941	filamentous actin