InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clcn5

Summary

InnateDB Protein

IDBP-128944.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clcn5

Protein Name

chloride channel 5

Synonyms

5430408K11Rik; ClC-5; Clc5; D930009B12Rik; DXImx42e; Sfc13; T25545;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004428

InnateDB Gene

IDBG-128942 (Clcn5)

Protein Structure

UniProt Annotation

Function

Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Kidney specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0005524	ATP binding
GO:0015297	antiporter activity
GO:0030554	adenyl nucleotide binding

Biological Process

GO:0006821	chloride transport
GO:0006897	endocytosis
GO:0034220	ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell