InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aip

Summary

InnateDB Protein

IDBP-128970.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aip

Protein Name

aryl-hydrocarbon receptor-interacting protein

Synonyms

AA408703; Ara9; AW476050; D19Bwg1412e; Fkbp16; Xap2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025767

InnateDB Gene

IDBG-128968 (Aip)

Protein Structure

UniProt Annotation

Function

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0036004	GAF domain binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0006626	protein targeting to mitochondrion
GO:0006805	xenobiotic metabolic process
GO:0010738	regulation of protein kinase A signaling
GO:0022417	protein maturation by protein folding
GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:109622

InterPro

IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM

PF00254
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O08915