InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cav2

Summary

InnateDB Protein

IDBP-128999.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cav2

Protein Name

caveolin 2

Synonyms

AI447843;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000058

InnateDB Gene

IDBG-128997 (Cav2)

Protein Structure

UniProt Annotation

Function

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin. Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1- mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019905	syntaxin binding
GO:0031748	D1 dopamine receptor binding
GO:0042803	protein homodimerization activity
GO:0051219	phosphoprotein binding

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006897	endocytosis
GO:0006906	vesicle fusion
GO:0007005	mitochondrion organization
GO:0007029	endoplasmic reticulum organization
GO:0007088	regulation of mitosis
GO:0007268	synaptic transmission
GO:0008285	negative regulation of cell proliferation
GO:0016050	vesicle organization
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0048278	vesicle docking
GO:0048741	skeletal muscle fiber development
GO:0051259	protein oligomerization
GO:0060161	positive regulation of dopamine receptor signaling pathway
GO:0070836	caveola assembly

Cellular Component

GO:0000139	Golgi membrane
GO:0002080	acrosomal membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0009986	cell surface
GO:0016020	membrane
GO:0030133	transport vesicle
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm