InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Capza2

Summary

InnateDB Protein

IDBP-129055.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Capza2

Protein Name

capping protein (actin filament) muscle Z-line, alpha 2

Synonyms

1110053K06Rik; AW208808; Cappa2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015877

InnateDB Gene

IDBG-129053 (Capza2)

Protein Structure

UniProt Annotation

Function

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0008150	biological_process
GO:0030036	actin cytoskeleton organization
GO:0051693	actin filament capping

Cellular Component

GO:0008290	F-actin capping protein complex
GO:0016020	membrane
GO:0030863	cortical cytoskeleton
GO:0070062	extracellular vesicular exosome
GO:0071203	WASH complex