Version 5.4
Mus musculus Protein: Osbpl1a
Summary
InnateDB Protein IDBP-129091.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Osbpl1a
Protein Name oxysterol binding protein-like 1A
Synonyms G430090F17Rik; Gm753; ORP-1; Osbpl1b;
Species Mus musculus
Ensembl Protein ENSMUSP00000073957
InnateDB Gene IDBG-129085 (Osbpl1a)
Protein Structure
UniProt Annotation
Function Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (By similarity). {ECO:0000250}.
Subcellular Localization Late endosome {ECO:0000250}. Note=Co- localizes with RAB7A, RAB9A and LAMP1 in late endosomes. {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:12215260}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015485 cholesterol binding
Biological Process
GO:0006869 lipid transport
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1927551
InterPro IPR000648 Oxysterol-binding protein
IPR001849 Pleckstrin homology domain
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF01237
PF00169
PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00233
SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91XL9
PhosphoSite PhosphoSite-Q91XL9
TrEMBL Q3V156
UniProt Splice Variant
Entrez Gene 64291
UniGene Mm.490206
RefSeq NP_997413
MGI ID
MGI Symbol Osbpl1a
OMIM
CCDS CCDS29067
HPRD
IMGT
EMBL AB017026 AC102055 AC131672 AF394063 AK132676 AK168366 AY536214 BC076637
GenPept AAH76637 AAK71661 AAT06024 BAA33012 BAE21296 BAE40301

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca