Homo sapiens Protein: CCND2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-12914.5 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CCND2 | ||||||||||||||||||||||
Protein Name | cyclin D2 | ||||||||||||||||||||||
Synonyms | KIAK0002; MPPH3; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000261254 | ||||||||||||||||||||||
InnateDB Gene | IDBG-12912 (CCND2) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000269PubMed:18827403}. Cytoplasm {ECO:0000269PubMed:18827403}. Membrane {ECO:0000269PubMed:18827403}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR004367
Cyclin, C-terminal domain IPR006671 Cyclin, N-terminal IPR013763 Cyclin-like IPR014400 Cyclin A/B/D/E/F |
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PFAM |
PF02984
PF00134 |
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PRINTS | |||||||||||||||||||||||
PIRSF |
PIRSF001771
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SMART |
SM00385
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P30279 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P30279 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 894 | ||||||||||||||||||||||
UniGene | Hs.706277 | ||||||||||||||||||||||
RefSeq | NP_001750 | ||||||||||||||||||||||
HUGO | HGNC:1583 | ||||||||||||||||||||||
OMIM | 123833 | ||||||||||||||||||||||
CCDS | CCDS8524 | ||||||||||||||||||||||
HPRD | 00451 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF518005 AK291146 BC010958 BC089384 BT019847 CH471116 D13639 M88080 M88081 M88082 M88083 M90813 X68452 | ||||||||||||||||||||||
GenPept | AAA51926 AAA51928 AAH10958 AAH89384 AAM54041 AAV38650 BAA02802 BAF83835 CAA48493 EAW88851 | ||||||||||||||||||||||