InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wnt2

Summary

InnateDB Protein

IDBP-129146.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnt2

Protein Name

wingless-related MMTV integration site 2

Synonyms

2610510E18Rik; Int1l1; Irp; Mirp; Wnt-2; Wnt2a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000010941

InnateDB Gene

IDBG-129144 (Wnt2)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

In embryos in the developing allantois, pericardium heart, and ventral-lateral mesoderm; in adults in lung, brain, heart and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005125	cytokine activity
GO:0005515	protein binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030324	lung development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0055009	atrial cardiac muscle tissue morphogenesis
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060070	canonical Wnt signaling pathway
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060492	lung induction
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060716	labyrinthine layer blood vessel development
GO:0061180	mammary gland epithelium development
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0031012	extracellular matrix