InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lpin1

Summary

InnateDB Protein

IDBP-129217.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lpin1

Protein Name

lipin 1

Synonyms

4631420P06; fld; Kiaa0188; Lipin1; mKIAA0188;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070583

InnateDB Gene

IDBG-129213 (Lpin1)

Protein Structure

UniProt Annotation

Function

Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. {ECO:0000269PubMed:16950137}.

Subcellular Localization

Isoform 1: Mitochondrion outer membrane {ECO:0000269PubMed:21397848}. Cytoplasm {ECO:0000269PubMed:21397848}. Nucleus membrane {ECO:0000269PubMed:21397848}. Note=Recruited at the mitochondrion outer membrane following phosphatidic acid formation mediated by PLD6. In neuronals cells, isoform 1 is exclusively cytoplasmic. In 3T3-L1 pre-adipocytes, it primarily located in the cytoplasm.Isoform 2: Nucleus. Cytoplasm. Endoplasmic reticulum membrane. Note=Nuclear localization requires both CNEP1R1 and CTDNEP1. In neuronals cells, localized in both the cytoplasm and the nucleus. In 3T3-L1 pre-adipocytes, it is predominantly nuclear.

Disease Associations

Note=Defects in Lpin1 are the cause of the fatty liver dystrophy phenotype (fld). Fld mutant mices are characterized by neonatal fatty liver and hypertriglyceridemia that resolve at weaning, and neuropathy affecting peripheral nerve in adulthood. Adipose tissue deficiency, glucose intolerance and increased susceptibility to atherosclerosis are associated with this mutation too. Two independent mutant alleles are characterized in this phenotype, fld and fld2j.

Tissue Specificity

Specifically expressed in skeletal muscle. Also expressed prominently in adipose tissue, and testis. Lower expression also detected in kidney, lung, brain and liver. Isoform 1 is the predominant isoform in the liver. Isoform 2 is the major form in the brain. {ECO:0000269PubMed:16049017, ECO:0000269PubMed:17158099, ECO:0000269PubMed:19753306, ECO:0000269PubMed:22134922}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008195	phosphatidate phosphatase activity
GO:0042826	histone deacetylase binding
GO:0042975	peroxisome proliferator activated receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000266	mitochondrial fission
GO:0006351	transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0006642	triglyceride mobilization
GO:0009062	fatty acid catabolic process
GO:0016311	dephosphorylation
GO:0019432	triglyceride biosynthetic process
GO:0031065	positive regulation of histone deacetylation
GO:0031100	organ regeneration
GO:0031529	ruffle organization
GO:0031532	actin cytoskeleton reorganization
GO:0032869	cellular response to insulin stimulus
GO:0045444	fat cell differentiation
GO:0045598	regulation of fat cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0005789	endoplasmic reticulum membrane
GO:0031965	nuclear membrane