InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lpin1

Summary

InnateDB Gene

IDBG-129213.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lpin1

Gene Name

lipin 1

Synonyms

4631420P06; fld; Kiaa0188; Lipin1; mKIAA0188

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020593

Encoded Proteins

IDBP-129217

lipin 1

IDBP-258899

lipin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134324:
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their full-length structures have not been determined. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:16535669-16589770

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000067124	ENSMUSP00000070583
ENSMUST00000111067	ENSMUSP00000106696

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008195	phosphatidate phosphatase activity
GO:0042826	histone deacetylase binding
GO:0042975	peroxisome proliferator activated receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000266	mitochondrial fission
GO:0006351	transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0006642	triglyceride mobilization
GO:0009062	fatty acid catabolic process
GO:0016311	dephosphorylation
GO:0019432	triglyceride biosynthetic process
GO:0031065	positive regulation of histone deacetylation
GO:0031100	organ regeneration
GO:0031529	ruffle organization
GO:0031532	actin cytoskeleton reorganization
GO:0032869	cellular response to insulin stimulus
GO:0045444	fat cell differentiation
GO:0045598	regulation of fat cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0005789	endoplasmic reticulum membrane
GO:0031965	nuclear membrane