InnateDB Protein
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IDBP-129239.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rad9
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Protein Name
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RAD9 homolog (S. pombe)
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Synonyms
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Rad9;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000025740
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InnateDB Gene
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IDBG-129237 (Rad9)
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Protein Structure
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Function |
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269PubMed:9766521}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
26 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1328356
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InterPro |
IPR007268
Rad9/Ddc1
IPR026584
Rad9
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PFAM |
PF04139
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PRINTS |
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PIRSF |
PIRSF009303
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z0F6
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PhosphoSite |
PhosphoSite-Q9Z0F6
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TrEMBL |
Q8QZZ4
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UniProt Splice Variant |
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Entrez Gene |
19367
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UniGene |
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RefSeq |
NP_035367
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MGI ID |
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MGI Symbol |
Rad9a
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OMIM |
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CCDS |
CCDS29422
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HPRD |
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IMGT |
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EMBL |
AF045662
AF045663
AF469740
AF469741
AF469742
AF469743
AF469744
AF469745
AF469746
AF469747
AF469748
AF469749
AF469750
AF469751
AF469752
AF469753
AK134293
BC082556
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GenPept |
AAC77364
AAC77365
AAH82556
AAL82387
AAL82388
AAL82389
AAL82390
AAL82391
AAL82392
AAL82393
AAL82448
AAL82449
AAL82450
AAL82451
AAL82452
AAL82453
AAL82454
BAE22086
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