Version 5.4
Mus musculus Gene: Rad9
Summary
InnateDB Gene IDBG-129237.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rad9
Gene Name RAD9 homolog (S. pombe)
Synonyms Rad9
Species Mus musculus
Ensembl Gene ENSMUSG00000024824
Encoded Proteins
IDBP-129239
RAD9 homolog (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172613:
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3\' to 5\' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:4195198-4201603
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025740 ENSMUSP00000025740
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0008853 exodeoxyribonuclease III activity
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0042826 histone deacetylase binding
Biological Process
GO:0000075 cell cycle checkpoint
GO:0000077 DNA damage checkpoint
GO:0000738 DNA catabolic process, exonucleolytic
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0031573 intra-S DNA damage checkpoint
GO:0071479 cellular response to ionizing radiation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030896 checkpoint clamp complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000172613
View Gene Order
ENSBTAG00000012141
Not yet available
Pathways
NETPATH
REACTOME
REACT_188804
Cell Cycle pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_235397
G2/M Checkpoints pathway
REACT_232236
Activation of ATR in response to replication stress pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_828
G2/M Checkpoints pathway
REACT_115566
Cell Cycle pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
atm_pathway
ATM pathway
atr_pathway
ATR signaling pathway
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt Q9Z0F6
TrEMBL Q8QZZ4
UniProt Splice Variant
Entrez Gene 19367
UniGene
RefSeq NM_011237
OMIM
CCDS CCDS29422
HPRD
IMGT
MGI ID MGI:1328356
MGI Symbol Rad9a
EMBL AF045662 AF045663 AF469740 AF469741 AF469742 AF469743 AF469744 AF469745 AF469746 AF469747 AF469748 AF469749 AF469750 AF469751 AF469752 AF469753 AK134293 BC082556
GenPept AAC77364 AAC77365 AAH82556 AAL82387 AAL82388 AAL82389 AAL82390 AAL82391 AAL82392 AAL82393 AAL82448 AAL82449 AAL82450 AAL82451 AAL82452 AAL82453 AAL82454 BAE22086
RNA Seq Atlas 19367

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca