InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Syp

Summary

InnateDB Protein

IDBP-129244.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syp

Protein Name

synaptophysin

Synonyms

A230093K24Rik; AI848995; p38; Syn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069429

InnateDB Gene

IDBG-129240 (Syp)

Protein Structure

UniProt Annotation

Function

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity. {ECO:0000250, ECO:0000269PubMed:10595519}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0015485	cholesterol binding
GO:0017075	syntaxin-1 binding
GO:0019904	protein domain specific binding
GO:0032403	protein complex binding
GO:0042169	SH2 domain binding
GO:0042802	identical protein binding

Biological Process

GO:0006897	endocytosis
GO:0007268	synaptic transmission
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0071310	cellular response to organic substance
GO:2000474	regulation of opioid receptor signaling pathway

Cellular Component

GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0030054	cell junction
GO:0030285	integral component of synaptic vesicle membrane
GO:0030672	synaptic vesicle membrane
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043229	intracellular organelle
GO:0043234	protein complex
GO:0044306	neuron projection terminus
GO:0045202	synapse
GO:0048786	presynaptic active zone
GO:0060076	excitatory synapse