InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clcf1

Summary

InnateDB Protein

IDBP-129273.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clcf1

Protein Name

cardiotrophin-like cytokine factor 1

Synonyms

Bsf3; CLC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045562

InnateDB Gene

IDBG-129271 (Clcf1)

Protein Structure

UniProt Annotation

Function

Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. {ECO:0000269PubMed:10500198}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005127	ciliary neurotrophic factor receptor binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002639	positive regulation of immunoglobulin production
GO:0002830	positive regulation of type 2 immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007259	JAK-STAT cascade
GO:0008284	positive regulation of cell proliferation
GO:0030183	B cell differentiation
GO:0030890	positive regulation of B cell proliferation
GO:0040007	growth
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043524	negative regulation of neuron apoptotic process
GO:0048295	positive regulation of isotype switching to IgE isotypes
GO:0048711	positive regulation of astrocyte differentiation
GO:0050727	regulation of inflammatory response
GO:0051466	positive regulation of corticotropin-releasing hormone secretion
GO:0051896	regulation of protein kinase B signaling
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:2000672	negative regulation of motor neuron apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0097058	CRLF-CLCF1 complex
GO:0097059	CNTFR-CLCF1 complex