InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdh2

Summary

InnateDB Protein

IDBP-129547.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdh2

Protein Name

cadherin 2

Synonyms

CDHN; N-cadherin; Ncad;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025166

InnateDB Gene

IDBG-129545 (Cdh2)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence (PubMed:24952463). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. {ECO:0000269PubMed:11433297, ECO:0000269PubMed:17988630, ECO:0000269PubMed:24952463}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019903	protein phosphatase binding
GO:0045294	alpha-catenin binding
GO:0045295	gamma-catenin binding

Biological Process

GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0016339	calcium-dependent cell-cell adhesion
GO:0016477	cell migration
GO:0043410	positive regulation of MAPK cascade
GO:0048514	blood vessel morphogenesis
GO:0051146	striated muscle cell differentiation
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005916	fascia adherens
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016342	catenin complex
GO:0030027	lamellipodium
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome