InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chrm3

Summary

InnateDB Protein

IDBP-129550.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrm3

Protein Name

cholinergic receptor, muscarinic 3, cardiac

Synonyms

Chrm-3; M3; M3R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055579

InnateDB Gene

IDBG-129548 (Chrm3)

Protein Structure

UniProt Annotation

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0008144	drug binding
GO:0015464	acetylcholine receptor activity
GO:0016907	G-protein coupled acetylcholine receptor activity
GO:0042166	acetylcholine binding

Biological Process

GO:0003056	regulation of vascular smooth muscle contraction
GO:0006939	smooth muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0007271	synaptic transmission, cholinergic
GO:0007586	digestion
GO:0043087	regulation of GTPase activity
GO:0045987	positive regulation of smooth muscle contraction
GO:0046541	saliva secretion

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032279	asymmetric synapse
GO:0043679	axon terminus
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:88398

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000995 Muscarinic acetylcholine receptor family
IPR001183 Muscarinic acetylcholine receptor M3
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00243
PR00540

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ERZ3