Version 5.4
Mus musculus Gene: Chrm3
Summary
InnateDB Gene IDBG-129548.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chrm3
Gene Name cholinergic receptor, muscarinic 3, cardiac
Synonyms Chrm-3; M3; M3R
Species Mus musculus
Ensembl Gene ENSMUSG00000046159
Encoded Proteins
IDBP-129550
cholinergic receptor, muscarinic 3, cardiac
IDBP-789190
cholinergic receptor, muscarinic 3, cardiac
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133019:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:9875486-10360844
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000063093 ENSMUSP00000055579
ENSMUST00000187510 ENSMUSP00000140131
ENSMUST00000190395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0015464 acetylcholine receptor activity
GO:0016907 G-protein coupled acetylcholine receptor activity
GO:0042166 acetylcholine binding
Biological Process
GO:0003056 regulation of vascular smooth muscle contraction
GO:0006939 smooth muscle contraction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0007271 synaptic transmission, cholinergic
GO:0007586 digestion
GO:0019229 regulation of vasoconstriction
GO:0043087 regulation of GTPase activity
GO:0045987 positive regulation of smooth muscle contraction
GO:0046541 saliva secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0032279 asymmetric synapse
GO:0043679 axon terminus
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000133019
View Gene Order
ENSBTAG00000008059
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_252999
Amine ligand-binding receptors pathway
REACT_217323
Integration of energy metabolism pathway
REACT_240390
Muscarinic acetylcholine receptors pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_247495
Acetylcholine regulates insulin secretion pathway
REACT_188937
Metabolism pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_231468
GPCR ligand binding pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04971
Gastric acid secretion pathway
mmu04970
Salivary secretion pathway
mmu04972
Pancreatic secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_16943
Muscarinic acetylcholine receptors pathway
REACT_16983
Amine ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_18405
Acetylcholine regulates insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_111217
Metabolism pathway
REACT_211803
Muscarinic acetylcholine receptors pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_209110
Regulation of insulin secretion pathway
REACT_205369
Signaling by GPCR pathway
REACT_217101
Integration of energy metabolism pathway
REACT_223458
Amine ligand-binding receptors pathway
REACT_214353
Signal Transduction pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_219139
Metabolism pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
REACT_202864
Acetylcholine regulates insulin secretion pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_033269 XM_006516467 XM_006516468
OMIM
CCDS CCDS26238
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca