InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp6v1c2

Summary

InnateDB Protein

IDBP-129665.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v1c2

Protein Name

ATPase, H+ transporting, lysosomal V1 subunit C2

Synonyms

1110038G14Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020884

InnateDB Gene

IDBG-129661 (Atp6v1c2)

Protein Structure

UniProt Annotation

Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subcellular Localization

Disease Associations

Tissue Specificity

Predominantly expressed in the lung and kidney. Isoform 1 is lung-specific while isoform 3 is a kidney- specific isoform. Isoform 1 is localized in the lamellar bodies of type II alveolar cells. Isoform 2 is strongly expressed in the cortical and medulla collecting ducts and is found in the plasma membranes of renal alpha and beta intercalated cells. {ECO:0000269PubMed:12527205, ECO:0000269PubMed:12947086}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0046983	protein dimerization activity